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NR5A2 Antibody

  • 中文名稱:
    NR5A2兔多克隆抗體
  • 貨號:
    CSB-PA016066LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, PC-3 whole cell lysate, HepG2 whole cell lysate, Mouse kidney tissue, Mouse brain tissue
      All lanes: NR5A2 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 62, 57, 43, 54 kDa
      Observed band size: 62, 54 kDa
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA016066LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human glioma using CSB-PA016066LA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NR5A2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NR5A2
  • 別名:
    Alpha-1-fetoprotein transcription factor antibody; B1-binding factor antibody; B1F antibody; B1F2 antibody; CPF antibody; CYP7A promoter-binding factor antibody; FTF antibody; FTZ F1 antibody; FTZ F1beta antibody; FTZ-F1 antibody; FTZ-F1beta antibody; hB1F 2 antibody; hB1F antibody; hB1F-2 antibody; Hepatocytic transcription factor antibody; Liver receptor homolog 1 antibody; LRH-1 antibody; LRH1 antibody; Nr5a2 antibody; NR5A2_HUMAN antibody; Nuclear receptor subfamily 5 group A member 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Nuclear receptor subfamily 5 group A member 2 protein (182-291AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,NR5A2 Antibody (CSB-PA016066LA01HU),的標記方式是Non-conjugated。對于NR5A2 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA016066LB01HU NR5A2 Antibody, HRP conjugated ELISA
    FITC CSB-PA016066LC01HU NR5A2 Antibody, FITC conjugated
    Biotin CSB-PA016066LD01HU NR5A2 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38.
  • 基因功能參考文獻:
    1. Lrh-1 transcriptionally regulates Oat2. PMID: 29669824
    2. Rev-erbalpha regulates Cyp7a1 and cholesterol metabolism through its repression of the Lrh-1 receptor. PMID: 29237721
    3. transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas; findings support the notion that, in the pancreas, the transcriptional networks involved in differentiation-specific functions also suppress inflammatory programs; under conditions of genetic or environmental constraint, these networks can be subverted to foster inflammation PMID: 29443959
    4. our data indicated that miR-381 inhibited migration and invasion of non-small cell lung cancer (NSCLC)by targeting LRH-1, and may represent a novel potential therapeutic target and prognostic marker for NSCLC. PMID: 29048619
    5. NR5A2-mediated cancer cell survival is facilitated through augmentation of GATA6 and anti-apoptotic factor BCL-XL levels. PMID: 27586588
    6. the expression level of LRH-1 can be used as a marker in the early diagnosis of unexplained recurrent spontaneous abortion. PMID: 28531169
    7. Liver receptor homologue1 (LRH1) is a direct target of miR30d in colorectal carcinoma cells. PMID: 28440426
    8. Results show that LRH-1 is a direct target gene of miR-374b and that decreased miR-374b expression may contribute to the promotion of LRH-1-mediated tumorigenesis of colon cancer. PMID: 29128635
    9. NR5A2 may be important in the pathophysiology of preterm birth and exploring noncoding regulators of NR5A2 is warranted PMID: 26761123
    10. Our study suggests that miR-219-5p regulated the proliferation, migration, and invasion of human gastric cancer cells by suppressing LRH-1. PMID: 27983934
    11. Liver receptor homolog-1 was identified as a direct target gene of miR-136 PMID: 28710032
    12. miR-27b-3p levels were found to be significantly negatively correlated with both NR5A2 and CREB1 levels in breast cancer tissues. PMID: 27809310
    13. The fusion transcript NR5A2-KLHL29FT was identified in normal and cancerous colonic epithelia. It is due to an uncharacterized polymorphic germline insertion of the NR5A2 sequence from chromosome 1 into the KLHL29 locus at chromosome 2, rather than a chromosomal rearrangement. NR5A2-KLH29FT expression levels were significantly lower in colon cancers than in matched normal colonic epithelia. PMID: 28081303
    14. Additionally, the authors solved the structure of the human LRH-1 DNA-binding domain bound to a DR0 motif located within the Oct4 promoter. PMID: 27984042
    15. miR-376c inhibits non-small-cell lung cancer cell growth and invasion by targeting LRH-1 PMID: 27049310
    16. The first crystal structure of the LRH-1-PGC1alpha complex , which depicts hydrophobic contacts is identified and described. PMID: 28363985
    17. The dramatic repositioning is influenced by a differential ability to establish stable face-to-face pi-pi-stacking with the LRH-1 residue His-390, as well as by a novel polar interaction mediated by the RJW100 hydroxyl group. The differing binding modes result in distinct mechanisms of action for the two agonists. PMID: 27694446
    18. The role of NR5A2 in regulating pancreatic cancer stem cell properties and epithelial-mesenchymal transition of pancreatic carcinoma cells PMID: 27996162
    19. demonstrate aberrant expressions of SF-1 and LRH-1 in endometriotic granulosa-lutein cells PMID: 26530052
    20. Down-regulation of MicroRNA-381 promotes cell proliferation and invasion in colon cancer cells through up-regulation of LRH-1. PMID: 26320367
    21. The present study indicates that miR-381 may be a novel tumor suppressor that blocks HCC growth and invasion by targeting LRH-1. PMID: 26677080
    22. The SNPs rs3790843 and rs3790844 in the NR5A2 gene are associated with pancreatic cancer risk in Japanese subjects. PMID: 26592175
    23. SERBP1 is a component of the LRH-1 transcriptional complex. PMID: 26398198
    24. These findings demonstrate that in vitro LRH-1 can act like SF-1 and compensate for its deficiency. PMID: 25896302
    25. These findings show that POD-1/TCF21 regulates SF-1 and LRH-1 by distinct mechanisms, contributing to the understanding of POD-1 involvement and its mechanisms of action in adrenal and liver tumorigenesis. PMID: 26421305
    26. Studies indicate that liver receptor homolog-1 (LRH-1) is critical involvement in multiple types of cancer, and represents a desirable target for therapeutic applications. PMID: 25951367
    27. in spermatozoa the LRH-1 effects are closely integrated with the estrogen signaling, supporting LRH-1 as a downstream effector of the estradiol pathway on some sperm functions. PMID: 26241668
    28. LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner. PMID: 26400164
    29. Data suggest LRH1/NR5A2 exhibits phospholipid-mediated allosteric control of protein-protein binding interface in interactions with TIF2 (co-activator; transcription intermediary factor 2) and SHP (co-repressor; small heterodimer partner protein). PMID: 26553876
    30. Results identify LRH-1 as a critical component of the anti-inflammatory and fungicidal response of alternatively activated macrophages that acts upstream from the IL-13-induced 15-HETE/PPARgamma axis. PMID: 25873311
    31. AFPR may play a pivotal role in HBV-related hepatocarcinogenesis. PMID: 25943101
    32. our findings present supportive evidence that ApoM is a regulator of human LRH-1 transcription, and further reveal the importance of ApoM as a critical regulator of bile acids metabolism PMID: 25987835
    33. these data demonstrate that copper-mediated nuclear receptor dysfunction disrupts liver function in WD and potentially in other disorders associated with increased hepatic copper levels. PMID: 26241054
    34. Analysis of breast cancer samples reveals that a high LRH-1 level is inversely correlated with CDKN1A expression in breast cancer patients and is associated with poor prognosis PMID: 25435372
    35. loss of LRH-1 by siRNA or miR-451 mimics significantly impaired Wnt/beta-catenin activity, leading to G0/G1 cell cycle arrest PMID: 25869073
    36. the NR5A2 rs3790844 polymorphism is associated with increased OS of GC patients in the dominant model, and similar results were found among the female group and tumor size >5 cm group for NR5A2 rs3790843 polymorphism. PMID: 25514243
    37. This study demonstrates a critical proproliferative role for LRH-1 in established colon cancer cell lines. PMID: 25675535
    38. during chronic colitis, TNF suppresses intestinal steroidogenic gene expression by inhibiting the activity of NR5A2, thus decreasing glucocorticoid synthesis and sustaining chronic inflammation. PMID: 24570488
    39. LRH1 overexpression is associated with increased pancreatic cancer growth and metastatic spread PMID: 24769073
    40. Data (including data from transgenic overexpression/gene silencing) suggest that NR5A2 modulates signal transduction/cell proliferation in mammary cells; mammary morphology exhibits significant reduction in lateral budding after NR5A2 overexpression. PMID: 24564400
    41. report the genome-wide location and molecular function of LRH-1 in breast cancer cells and reveal its therapeutic potential for the treatment of breast cancers, notably for tumors resistant to treatments currently used in therapies. PMID: 24520076
    42. Data conclude that SF-1 regulates aromatase expression in GCT; over-expression of LRH-1 suggests that this receptor may be involved in the pathogenesis of GCT by mechanisms other than the regulation of aromatase. PMID: 23537609
    43. Lrh-1 is necessary for maintenance of the corpus luteum, for promotion of decidualization and for formation of the placenta. PMID: 23817023
    44. Data indicate that sequence divergence has differentially impacted ligand binding and protein dynamics in NR5A2. PMID: 23737522
    45. Experimental evaluation of the predicted ligands identified two compounds that inhibit the transcriptional activity of LRH-1 and diminish the expression of the receptor's target genes. PMID: 23667258
    46. Expression of human LRH-1 is regulated in a tissue-specific manner, and that the novel promoter region is controlled by the Sp-family, NR5A-family and PGC-1alpha in ovarian granulosa cells in a coordinated fashion. PMID: 23471216
    47. this study indicates that LRH-1 acts as a transcriptional activator in the regulation of OCT4 gene expression through the cooperative interaction with three binding sites directly or/and indirectly. PMID: 23000165
    48. HNF4alpha and LRH-1 promote active transcription histone marks on the Cyp7a1 promoter that are reversed by FGF19 in a SHP-dependent manner PMID: 23038264
    49. The lipid-free receptor undergoes previously unrecognized structural fluctuations, allowing it to interact with widely expressed co-repressors. PMID: 22504882
    50. Data show that single nucleotide polymorphisms (SNPs) in ABO, sonic hedgehog (SHH), telomerase reverse transcriptase (TERT), nuclear receptor subfamily 5, group A, member 2 (NR5A2) were found to be associated with pancreatic cancer risk. PMID: 22125638

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  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Nuclear hormone receptor family, NR5 subfamily
  • 組織特異性:
    Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in the Hep-G2 cell line. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and Hep-G2 cells.
  • 數據庫鏈接:

    HGNC: 7984

    OMIM: 604453

    KEGG: hsa:2494

    STRING: 9606.ENSP00000356331

    UniGene: Hs.33446



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